OcrV1, Main, Exploration, bibRecord, 000738

Calcium scores and matrix Gla protein levels: association with vitamin K status

Identifieur interne : 000738 ( Main/Exploration ); précédent : 000737; suivant : 000739

Calcium scores and matrix Gla protein levels: association with vitamin K status

Auteurs : Roger J. M. W. Rennenberg [Pays-Bas] ; Peter W. De Leeuw [Pays-Bas] ; Alphons G. H. Kessels [Pays-Bas] ; Leon J. Schurgers [Pays-Bas] ; Cees Vermeer [Pays-Bas] ; Jos M. A. Van Engelshoven [Pays-Bas] ; Gerrit J. Kemerink [Pays-Bas] ; Abraham A. Kroon [Pays-Bas]

Source :

European Journal of Clinical Investigation [ 0014-2972 ] ; 2010-04.

RBID : ISTEX:B2FF16625038B0D0167562A1B91E2279662047D8

Descripteurs français

Pascal (Inist)
- Assistance ordinateur, Association, Calcification, Calcium, Hypertension artérielle, Médecine, Ordinateur, Ostéocalcine, Protéine MGP, Ratio, Score, Tomographie, Vitamine K.
Wicri :
- topic : Association, Calcium, Médecine, Ordinateur, Ratio.

English descriptors

KwdEn :
- Association, Calcification, Calcium, Computer, Computer aid, Hypertension, Matrix Gla protein, Medicine, Osteocalcin, Ratio, Score, Tomography, Vitamin K, computer tomography, hypertension, matrix Gla protein, osteocalcin ratio, vitamin K.

Abstract

Eur J Clin Invest 2010; 40 (4): 344–349 Abstract: Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long‐term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z‐scores. Results The total calcium Z‐score was significantly correlated to age (r = 0·683, P < 0·001), smoking (r = 0·372, P = 0·026), total cholesterol (r = 0·353, P = 0·034), LDL cholesterol (r = 0·490, P = 0·003), triglycerides (r = 0·506, P = 0·002), fasting glucose (r = 0·454, P = 0·005), systolic blood pressure (r = 0·363, P = 0·029) and pulse pressure (r = 0·685, P < 0·001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.

Url:

https://api.istex.fr/document/B2FF16625038B0D0167562A1B91E2279662047D8/fulltext/pdf

DOI: 10.1111/j.1365-2362.2010.02275.x

Affiliations:

Pays-Bas

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcium scores and matrix Gla protein levels: association with vitamin K status</title>
<author><name sortKey="Rennenberg, Roger J M W" sort="Rennenberg, Roger J M W" uniqKey="Rennenberg R" first="Roger J. M. W." last="Rennenberg">Roger J. M. W. Rennenberg</name>
</author>
<author><name sortKey="De Leeuw, Peter W" sort="De Leeuw, Peter W" uniqKey="De Leeuw P" first="Peter W." last="De Leeuw">Peter W. De Leeuw</name>
</author>
<author><name sortKey="Kessels, Alphons G H" sort="Kessels, Alphons G H" uniqKey="Kessels A" first="Alphons G. H." last="Kessels">Alphons G. H. Kessels</name>
</author>
<author><name sortKey="Schurgers, Leon J" sort="Schurgers, Leon J" uniqKey="Schurgers L" first="Leon J." last="Schurgers">Leon J. Schurgers</name>
</author>
<author><name sortKey="Vermeer, Cees" sort="Vermeer, Cees" uniqKey="Vermeer C" first="Cees" last="Vermeer">Cees Vermeer</name>
</author>
<author><name sortKey="Van Engelshoven, Jos M A" sort="Van Engelshoven, Jos M A" uniqKey="Van Engelshoven J" first="Jos M. A." last="Van Engelshoven">Jos M. A. Van Engelshoven</name>
</author>
<author><name sortKey="Kemerink, Gerrit J" sort="Kemerink, Gerrit J" uniqKey="Kemerink G" first="Gerrit J." last="Kemerink">Gerrit J. Kemerink</name>
</author>
<author><name sortKey="Kroon, Abraham A" sort="Kroon, Abraham A" uniqKey="Kroon A" first="Abraham A." last="Kroon">Abraham A. Kroon</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B2FF16625038B0D0167562A1B91E2279662047D8</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1111/j.1365-2362.2010.02275.x</idno>
<idno type="url">https://api.istex.fr/document/B2FF16625038B0D0167562A1B91E2279662047D8/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000289</idno>
<idno type="wicri:Area/Istex/Curation">000284</idno>
<idno type="wicri:Area/Istex/Checkpoint">000318</idno>
<idno type="wicri:doubleKey">0014-2972:2010:Rennenberg R:calcium:scores:and</idno>
<idno type="wicri:Area/Main/Merge">000743</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0166437</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000198</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000579</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000168</idno>
<idno type="wicri:doubleKey">0014-2972:2010:Rennenberg R:calcium:scores:and</idno>
<idno type="wicri:Area/Main/Merge">000799</idno>
<idno type="wicri:Area/Main/Curation">000738</idno>
<idno type="wicri:Area/Main/Exploration">000738</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Calcium scores and matrix Gla protein levels: association with vitamin K status</title>
<author><name sortKey="Rennenberg, Roger J M W" sort="Rennenberg, Roger J M W" uniqKey="Rennenberg R" first="Roger J. M. W." last="Rennenberg">Roger J. M. W. Rennenberg</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Leeuw, Peter W" sort="De Leeuw, Peter W" uniqKey="De Leeuw P" first="Peter W." last="De Leeuw">Peter W. De Leeuw</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kessels, Alphons G H" sort="Kessels, Alphons G H" uniqKey="Kessels A" first="Alphons G. H." last="Kessels">Alphons G. H. Kessels</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC+), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schurgers, Leon J" sort="Schurgers, Leon J" uniqKey="Schurgers L" first="Leon J." last="Schurgers">Leon J. Schurgers</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biochemistry, Maastricht University, CARIM and VitaK B.V., Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vermeer, Cees" sort="Vermeer, Cees" uniqKey="Vermeer C" first="Cees" last="Vermeer">Cees Vermeer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biochemistry, Maastricht University, CARIM and VitaK B.V., Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Engelshoven, Jos M A" sort="Van Engelshoven, Jos M A" uniqKey="Van Engelshoven J" first="Jos M. A." last="Van Engelshoven">Jos M. A. Van Engelshoven</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemerink, Gerrit J" sort="Kemerink, Gerrit J" uniqKey="Kemerink G" first="Gerrit J." last="Kemerink">Gerrit J. Kemerink</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kroon, Abraham A" sort="Kroon, Abraham A" uniqKey="Kroon A" first="Abraham A." last="Kroon">Abraham A. Kroon</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Clinical Investigation</title>
<idno type="ISSN">0014-2972</idno>
<idno type="eISSN">1365-2362</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2010-04">2010-04</date>
<biblScope unit="volume">40</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="344">344</biblScope>
<biblScope unit="page" to="349">349</biblScope>
</imprint>
<idno type="ISSN">0014-2972</idno>
</series>
<idno type="istex">B2FF16625038B0D0167562A1B91E2279662047D8</idno>
<idno type="DOI">10.1111/j.1365-2362.2010.02275.x</idno>
<idno type="ArticleID">ECI2275</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0014-2972</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Calcification</term>
<term>Calcium</term>
<term>Computer</term>
<term>Computer aid</term>
<term>Hypertension</term>
<term>Matrix Gla protein</term>
<term>Medicine</term>
<term>Osteocalcin</term>
<term>Ratio</term>
<term>Score</term>
<term>Tomography</term>
<term>Vitamin K</term>
<term>computer tomography</term>
<term>hypertension</term>
<term>matrix Gla protein</term>
<term>osteocalcin ratio</term>
<term>vitamin K</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Assistance ordinateur</term>
<term>Association</term>
<term>Calcification</term>
<term>Calcium</term>
<term>Hypertension artérielle</term>
<term>Médecine</term>
<term>Ordinateur</term>
<term>Ostéocalcine</term>
<term>Protéine MGP</term>
<term>Ratio</term>
<term>Score</term>
<term>Tomographie</term>
<term>Vitamine K</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
<term>Calcium</term>
<term>Médecine</term>
<term>Ordinateur</term>
<term>Ratio</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Eur J Clin Invest 2010; 40 (4): 344–349 Abstract: Background  Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long‐term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods  In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z‐scores. Results  The total calcium Z‐score was significantly correlated to age (r = 0·683, P < 0·001), smoking (r = 0·372, P = 0·026), total cholesterol (r = 0·353, P = 0·034), LDL cholesterol (r = 0·490, P = 0·003), triglycerides (r = 0·506, P = 0·002), fasting glucose (r = 0·454, P = 0·005), systolic blood pressure (r = 0·363, P = 0·029) and pulse pressure (r = 0·685, P < 0·001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions  We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
</country>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Rennenberg, Roger J M W" sort="Rennenberg, Roger J M W" uniqKey="Rennenberg R" first="Roger J. M. W." last="Rennenberg">Roger J. M. W. Rennenberg</name>
</noRegion>
<name sortKey="De Leeuw, Peter W" sort="De Leeuw, Peter W" uniqKey="De Leeuw P" first="Peter W." last="De Leeuw">Peter W. De Leeuw</name>
<name sortKey="Kemerink, Gerrit J" sort="Kemerink, Gerrit J" uniqKey="Kemerink G" first="Gerrit J." last="Kemerink">Gerrit J. Kemerink</name>
<name sortKey="Kessels, Alphons G H" sort="Kessels, Alphons G H" uniqKey="Kessels A" first="Alphons G. H." last="Kessels">Alphons G. H. Kessels</name>
<name sortKey="Kroon, Abraham A" sort="Kroon, Abraham A" uniqKey="Kroon A" first="Abraham A." last="Kroon">Abraham A. Kroon</name>
<name sortKey="Schurgers, Leon J" sort="Schurgers, Leon J" uniqKey="Schurgers L" first="Leon J." last="Schurgers">Leon J. Schurgers</name>
<name sortKey="Van Engelshoven, Jos M A" sort="Van Engelshoven, Jos M A" uniqKey="Van Engelshoven J" first="Jos M. A." last="Van Engelshoven">Jos M. A. Van Engelshoven</name>
<name sortKey="Vermeer, Cees" sort="Vermeer, Cees" uniqKey="Vermeer C" first="Cees" last="Vermeer">Cees Vermeer</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/OcrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000738 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000738 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    OcrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:B2FF16625038B0D0167562A1B91E2279662047D8
   |texte=   Calcium scores and matrix Gla protein levels: association with vitamin K status
}}

This area was generated with Dilib version V0.6.32.
Data generation: Sat Nov 11 16:53:45 2017. Site generation: Mon Mar 11 23:15:16 2024

Serveur d'exploration sur l'OCR

Calcium scores and matrix Gla protein levels: association with vitamin K status

Calcium scores and matrix Gla protein levels: association with vitamin K status

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur l'OCR
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.